Centennial needs a win over a Cimarron-Memorial team that is out of the playoff race to claim its first league title since 2002 and the No. 1 seed in the Northwest League.
Martin Blake ran for 113 yards and a touchdown and returned a punt for a score to help the Pioneers to a 48-7 Southeast League win over Eldorado.
Garrett Castro threw a 6-yard touchdown pass, and Hector Barrios-Baez knocked home the game-winning extra point for Green Valley in a 24-23 win over Foothill.
Centennial was the fourth straight team that the Patriots have faced to start the season that finished 2018 ranked in the top 40 nationally.