The Buckeyes, who have beaten their four Big Ten opponents by an average of 38.8 points, are consensus 14½-point favorites.
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Boston College is working on four covers in a row and is 10-3 against the spread in its last 13 road games.
CG Technology sportsbook initially took a bet on the Redskins at plus 16 but sharp bettors jumped on the Vikings at minus 15½ before public money pushed it to 16½.
After covering in a 30-23 win over the Texans, the Colts improved to an NFL-best 4-1-1 against the spread this season.