Senior running back Noah Hawthorne rushed for 176 yards and three touchdowns, and the Gators never looked back in taking a 34-6 win over the Trailblazers.
Bishop Gorman, Green Valley, Liberty and Silverado hosting first-round games. Arbor View and Palo Verde meet with a Mountain Region home playoff game on the line.
Centennial needs a win over a Cimarron-Memorial team that is out of the playoff race to claim its first league title since 2002 and the No. 1 seed in the Northwest League.
Martin Blake ran for 113 yards and a touchdown and returned a punt for a score to help the Pioneers to a 48-7 Southeast League win over Eldorado.