William Hill won more than $1 million on Washington, which was reportedly only the second team in 25 years to cover the spread without scoring in a 9-0 loss to the 49ers.
The Dolphins (0-5) covered in a 17-16 loss to the Redskins and the Jets (1-4) earned their first win in a 24-22 upset victory over the Cowboys.
The Sooners are 10½-point favorites over Texas in the Red River Showdown after the line was as high as 11½, and the Irish are 10½-point favorites over USC.
Sharp money on Chicago drove the line from 5½ to 6½ and MGM Resorts took a six-figure bet on the Bears. The Raiders gave William Hill its only win of the 10 a.m. games.
The Buckeyes rolled 48-7 Saturday at Nebraska — torching so-called sharp money on the Cornhuskers — and are 20-point home favorites Saturday over Michigan State.
NFL underdogs went 9-3-1 against the spread with seven outright upsets Sunday as Las Vegas sportsbooks had their best day of the season, by far.
The Cornhuskers are 7-1 against the spread in their last eight Big Ten games, and coach Scott Frost is on a 7-2 cover run as an underdog.
The Rams’ 20-13 win was the biggest NFL decision of the season for MGM Resorts and CG Technology, which each needed Cleveland for multiple six figures.
Ed Salmons, Westgate sportsbook vice president of risk management, said the Bulldogs are motivated to embarrass the Fighting Irish in a game between top 10 teams.
New England is the team that America loves to hate but it also loves to bet on the Patriots, who easily covered the 18½-point spread in a 43-0 road rout of the Dolphins.