Substance, an 18,000-square-foot nightclub, debuts in Neonopolis in downtown Las Vegas with a chic warehouse vibe.
Nightlife
No. 1 is a no-brainer, but some of the cities in the top 10 might be considered head-scratchers.
In celebration of America’s best party destination, Stacker spotlighted 20 iconic parties and party venues from Las Vegas history. From over-the-top billionaire birthday bashes to the craziest celebrity bachelor parties, the tales of these blowouts are sure to make your jaw drop.