There are countless cases of unranked teams being favored over ranked teams and ranked teams being favored over teams ranked above them in the college polls.
Football
Penn State is 0-4 straight up and against the spread this season and is on a 2-7 spread skid since late 2019. Iowa is 16-8-1 ATS in its last 25 conference road games.
Seattle is a 3-point home favorite against Arizona. The teams are locked in a three-way tie with the Los Angeles Rams atop the NFC West.
The Dolphins and Steelers have the NFL’s best records against the spread so far this season at 7-2.
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