Road work will close the 215 Beltway in both directions at the Centennial Bowl in the northwest valley.
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A fatal crash on northbound Interstate 15 after Washington Avenue Sunday was under investigation.
The man exited the car after the crash and ran a short distance before collapsing, police said.
Bus routes, roads and parking lots will be closed or altered during the three-day event.
The widening of the 215 Beltway in the south valley and work on Centennial Bowl in the northwest will add to traffic issues.
There are signs the shoulder lane on the California side might be working, but heading south remained no speedy process on a holiday weekend.
Officials are anticipating a lot of traffic at the Las Vegas airport over Labor Day weekend.