Tyson, 53, and Holyfield, 57, each have posted impressive workout videos on social media and expressed a desire to return to the ring for an exhibition match for charity.
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Floyd Mayweather Jr. by knockout is the minus-200 favorite in method-of-victory props for his Aug. 26 boxing match against Conor McGregor.
Early betting interest on the bout has been nonexistent at the Westgate, which posted odds on the possible megafight Thursday with Mayweather listed as a 25-1 favorite and McGregor a 11-1 underdog.