The Golden Knights have won 35 of their past 39 games, including their past four season openers, and scored 31 points or more in all but one game during that stretch.
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Handicappers Paul Stone, Wes Reynolds and Ian Cameron each went 4-1 ATS in Week 1 to take the lead in the college football contest.
The Rams entered 2020 on a 14-7 spread uptick. Coach Sean McVay is 5-3 as an underdog since 2017 and 9-3 against the spread in his last 12 games away from Los Angeles.
Syracuse has a converted fullback/tight end as a starter on an offensive line that gave up seven sacks in a 31-6 loss to North Carolina.