The fourth-year running back went for a career-high 144 yards on 28 carries and scored two touchdowns in a 32-23 win against AFC West rival Denver.
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The betting public was all over the Colts in a game that saw the line soar to 8½ on Sunday when Indianapolis quarterback Carson Wentz was cleared to play.
Henry Ruggs chose to get behind the wheel when reportedly impaired Tuesday morning and then was involved in a fiery crash that left a woman dead.