The road will be closed in the area for several hours while an investigation is underway, the Henderson Police Department said on Twitter.
Beginning Monday, Las Vegas Boulevard from Spring Mountain Road to Sahara Avenue will be restricted to one or two lanes in each direction from 12:30 a.m. to 11 a.m. on weekdays.
The crash was reported just before 11:40 a.m. on southbound U.S. Highway 95 near the Decatur Boulevard exit, according to the Nevada Highway Patrol.
Originally slated to open in July, then delayed until November, the pedestrian bridge linking Park MGM and the Showcase Mall could open as early as Dec. 23.
The crash occurred about 3 a.m. in the northbound lanes of Pecos Road near East Lake Mead Boulevard, according to Metropolitan Police Department Lt. Ken Nogle.
The Nevada Highway Patrol has been dispatched on nearly 400 calls for wrong-way drivers in Southern Nevada so far this year, according to the agency.
Las Vegas police responded to Interstate 15 and Russell Road on Tuesday after a man shot at an off-duty officer, police said.
One of the final unfinished pieces of the nearly $1 billion Project Neon freeway improvement project is nearing activation, albeit later than transportation officials planned.
Help is on the way, but changes to the U.S. 95/215/Lake Mead Parkway interchange are still up to 10 years away.
The Metropolitan Police Department received a report at 10:34 a.m. of a man who was walking in traffic, “appearing to try to get hit,” Lt. Jeff Stuart said.