Kansas City (4-1), which closed as a 10½-point favorite, suffered its first loss of the season in a 19-13 defeat to Indianapolis on Sunday night at Arrowhead Stadium.
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South Point took a $55,000 bet on San Francisco minus 3½, the Westgate took a $33,000 wager on the Niners minus 4 and CG Technology took sharp bets on them at 3½ and 4.