Win and the Raiders are off to London to play Khalil Mack and the Bears with a 2-2 record. But lose and they are 1-3 and looking at a 1-6 start to the season.
Defensive back Lamarcus Joyner could see his role exanded on defense as soon as this week.
The Panthers are on a 3-8 spread skid since late 2018, while the Texans are 9-3-1 against the spread in their last 13 regular-season games.
The four-time All-Pro wide receiver wrote on Twitter on Thursday: “I’m still the best why stop now.” He followed with the suggestion that the game needs him.