The Bills are on a 4-1-1 spread run and are 5-0-1 ATS on the road this season. The Steelers are on an 8-2-1 spread run.
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The Rams have covered three of their last four games and are tied with the Steelers for the best record in the NFL against the spread at 9-4.
Sharp bettors at the Westgate and CG Technology sportsbooks wagered on the Ravens as 15½-point favorites and the line was up to 16½ on Thursday afternoon.