Notre Dame is 0-3-1 ATS in its last four games as a road favorite. Duke is 1-1-1 as an underdog this season, but 27-13-2 in the role since 2013.
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Having already played its army-of-veterinarians and raceday-medication-limits cards, management may have to look at replacing its dirt track with a synthetic racing surface.
The Saints and the Rams both sit at 6-2 against the spread this season, tied for best in the NFL through nine weeks.