Besides the strike-shortened 1987 season, this is reportedly the first time since the 1970s that two NFL teams have been favored by at least 21 points in the same week.
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Ed Salmons, Westgate sportsbook vice president of risk management, said the Bulldogs are motivated to embarrass the Fighting Irish in a game between top 10 teams.
Utah is 20-8-1 against the spread on the road since 2014, and the Utes have covered their last three and four of five against Southern California.
Tennessee, a consensus 1½-point road favorite over Jacksonville, has won the last four meetings between the teams and six of the last seven.
The Cardinals have yet to win a game on the field, but the team is perfect against the spread through two weeks.