Martin Blake ran for 113 yards and a touchdown and returned a punt for a score to help the Pioneers to a 48-7 Southeast League win over Eldorado.
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Garrett Castro threw a 6-yard touchdown pass, and Hector Barrios-Baez knocked home the game-winning extra point for Green Valley in a 24-23 win over Foothill.
The Panthers (24-3, 9-0 Mountain League) have a two-game lead over Centennial, Rancho and Shadow Ridge with four matches remaining in the regular season.
The Eagles will host a 20-team field in the Boulder City Invitational, a week after ranking as the highest valley finisher in the Durango Fall Classic.
The Durango Fall Classic, a 64-team event with a mix of schools from the valley and others from all over the country, will be played at four schools Friday and Saturday.