Dwayne Harris of Georgia landed the largest of the four scores on Friday night at The Linq Hotel, winning $166,421 on a Three Card Poker mega jackpot.
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Dorothy Boone of Temple, Texas, had been playing for about an hour when she hit a royal flush in spades.
The winning spin occurred just before 6:30 p.m. Monday at Wynn Las Vegas.
Visitors on and off the Las Vegas Strip are celebrating $100,000 wins through different means.