The crash occurred shortly before 7 p.m. near Nellis Boulevard and Sandra Road, Las Vegas police said.
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The collision occurred about 6:30 p.m. near South Jones Boulevard and Badura Avenue, according to Metropolitan Police Department Lt. Aaron Lee.
In a six-hour period, a joint law enforcement effort caught 77 red light runners at Green Valley Parkway and the 215 Beltway.
The motorist was westbound on West Ann Road just west of North Jones Boulevard when her vehicle broke down. Impairment is suspected, police said.
Driver David Gomez-Mojarro, 16, and passenger Jovan Barrios, 17, were identified by the Clark County coroner’s office as being killed in the crash.
A shooting near Interstate 15 north of downtown Las Vegas left one person injured and caused a brief shutdown of the northbound lanes.