A Toyota minivan and a Yamaha collided at about 10:48 a.m. near South Eastern and East Wigwam Avenue, according to a Metropolitan Police Department release.
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More traffic disruptions are scheduled for Interstate 15 near Tropicana Avenue.
Nevada State Police reported a fatal crash on U.S. Highway 95 early Thursday morning.
Las Vegas police closed the I-15 freeway for about 20 minutes as they responded for a firearm call.
Motorcyclist Sonny Trushel, 18, of Las Vegas, died in a crash with a vehicle last Friday.
This weekend, drivers in downtown Las Vegas may be affected by closures on Las Vegas Boulevard.
Heavy snow closed several of the major roads leading to and from Las Vegas for parts of the day on Wednesday.
A stretch of Interstate 15, one of the most traveled roads in Nevada, is closed in the central valley all weekend.
A man was fatally struck by a vehicle that drove off Wednesday night in southeast Las Vegas.
The crash occurred around 3:50 p.m. near the 2100 block of Las Vegas Boulevard North.