The Metropolitan Police Department advised travelers to avoid the area.
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The Nevada Highway Patrol has been dispatched on nearly 400 calls for wrong-way drivers in Southern Nevada so far this year, according to the agency.
A state corrections officer was killed Tuesday afternoon in a two-vehicle crash involving a Nevada Department of Transportation truck on U.S. Highway 95 northwest of Las Vegas.
A 53-year-old Connecticut man died and another person was critically injured after a helicopter crash Wednesday afternoon in Red Rock Canyon National Conservation Area.
It was a particularly violent weekend in the Las Vegas valley, with at least eight deaths reported from Friday morning to Sunday night.
Las Vegas law enforcement joined forces with Stop DUI and the families of DUI victims to dedicate State Route 157 to victims of DUI incidents.
All lanes of Interstate 15 at Craig Road had reopened as of about 5:40 p.m., according to the National Highway Patrol Southern Command.
Two lanes on U.S. Highway 95 southbound at Decatur Boulevard have reopened after a crash involving three vehicles and a semitrailer.
Some portions of Interstate 15 will be closed for repairs Wednesday through Friday, according to the Nevada Department of Transportation.
Two pedestrians were critically injured when they were hit by a bus on the Las Vegas Strip early Tuesday.