The crash occurred shortly before 7 p.m. near Nellis Boulevard and Sandra Road, Las Vegas police said.
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The motorcyclist hit the front passenger door of sedan and died at the scene as did a passenger in the sedan, police said.
A $160 million project planned to upgrade the U.S. Highway 93-Interstate 40 interchange between Las Vegas and Phoenix will kick off next year.
The 34-year-old motorcyclist died after a collision at Craig and Kings Hill roads. North Las Vegas police said they believe speed was a factor in the crash.
The Nevada Department of Transportation has started the process of repairs roads damaged by Tropical Storm Hilary.
A 12-mile backup leading into Primm on I-15 was reported by the Regional Transpiration Commission.
A busy stretch of Eastern Avenue is set for a road improvement project that will result in lane impacts for the next couple of months.
The crash occurred at South Rainbow Boulevard and West Windmill Lane around 1:40 p.m.
A man believed to be in his 30s was killed when the motorcycle he was riding collided with a vehicle in North Las Vegas on Monday night.
An early-morning crash Monday in east Las Vegas has left a motorcyclist in critical condition.