Tropicana Avenue will be closed between Dean Martin Drive and New York-New York through 5 a.m. on Tuesday.
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Henderson police said they were investigating along with a Metropolitan Police Department helicopter, Henderson’s SWAT unit and Metro officers.
Clark County will send texts every Sunday announcing traffic impacts so motorists can plan for the week ahead.
The area is part of the Formula 1 race course and will be closing this evening for the first night practice sessions.
Police said the woman was taken to Sunrise Hospital and Medical Center with severe injuries, but later died at the hospital.
One of the most disruptive of the road closures tied to the Las Vegas Grand Prix circuit setup is scheduled to begin this week.
A portion of Tropicana Avenue in the resort corridor will close to traffic overnight for work tied to a project to improve the Tropicana/Interstate 15 interchange.
Fans looking to skip driving to attend the Golden Knights Stanley Cup championship parade on the Strip are in luck.
At least 11 people were injured, including one critically, Friday morning in crashes across the rainy Las Vegas valley.
The crash occurred around 2:40 p.m. south of Cheyenne Avenue.